Motif ID: FOX{I1,J2}.p2

Z-value: 1.638


Transcription factors associated with FOX{I1,J2}.p2:

Gene SymbolEntrez IDGene Name
FOXI1 2299 forkhead box I1
FOXJ2 55810 forkhead box J2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
FOXJ2chr12_+_80765080.741.0e-03Click!
FOXI1chr5_+_169465478-0.039.3e-01Click!


Activity profile for motif FOX{I1,J2}.p2.

activity profile for motif FOX{I1,J2}.p2


Sorted Z-values histogram for motif FOX{I1,J2}.p2

Sorted Z-values for motif FOX{I1,J2}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of FOX{I1,J2}.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr20_+_19818209 8.160 NM_018993
RIN2
Ras and Rab interactor 2
chr1_+_148747110 6.141 NM_004425
NM_022664
ECM1

extracellular matrix protein 1

chr3_+_160269734 4.592 NM_001197113
NM_001197114
NM_001042705
NM_001042706
NM_001197100
IQCJ-SCHIP1

IQCJ


IQCJ-SCHIP1 readthrough

IQ motif containing J


chr9_+_74956601 4.250 ANXA1
annexin A1
chr9_+_74956494 3.913 NM_000700
ANXA1
annexin A1
chr20_+_19863716 3.903 RIN2
Ras and Rab interactor 2
chr5_+_159368690 3.864 TTC1
tetratricopeptide repeat domain 1
chr9_+_123123364 3.791 GSN
gelsolin
chr12_-_90100679 3.708 DCN
decorin
chr5_+_159368721 3.655 TTC1
tetratricopeptide repeat domain 1
chr2_-_189752575 3.266 NM_000393
COL5A2
collagen, type V, alpha 2
chr1_-_77457664 3.143 NM_005482
PIGK
phosphatidylinositol glycan anchor biosynthesis, class K
chr5_+_159368733 3.106 NM_003314
TTC1
tetratricopeptide repeat domain 1
chr13_-_109600709 3.074 COL4A1
collagen, type IV, alpha 1
chr9_-_87904844 3.030 NM_177937
GOLM1
golgi membrane protein 1
chr12_-_90100733 2.912 NM_001920
DCN
decorin
chr11_+_113672378 2.704 NNMT
nicotinamide N-methyltransferase
chr3_-_150569574 2.608 TM4SF1
transmembrane 4 L six family member 1
chr11_+_113672407 2.600 NNMT
nicotinamide N-methyltransferase
chrX_+_135106578 2.583 NM_001159701
NM_001159699
FHL1

four and a half LIM domains 1

chr1_-_56817823 2.548 NM_003713
PPAP2B
phosphatidic acid phosphatase type 2B
chr6_+_121798443 2.441 NM_000165
GJA1
gap junction protein, alpha 1, 43kDa
chr1_-_56817802 2.397 PPAP2B
phosphatidic acid phosphatase type 2B
chr13_+_109932934 2.382 COL4A2
collagen, type IV, alpha 2
chr1_+_84382529 2.359 NM_182948
PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr9_+_74956614 2.344 ANXA1
annexin A1
chr2_+_200878848 2.328 NM_015535
SPATS2L
spermatogenesis associated, serine-rich 2-like
chr3_-_130761967 2.292 PLXND1
plexin D1
chr1_-_151866367 2.288 NM_001024212
S100A13
S100 calcium binding protein A13
chr1_-_151866147 2.243 NM_001024213
S100A13
S100 calcium binding protein A13
chr5_-_111340421 2.230 NM_001142474
NM_001142475
C5orf13

chromosome 5 open reading frame 13

chr5_+_53787187 2.202 NM_006308
HSPB3
heat shock 27kDa protein 3
chr13_+_48968097 2.155 PHF11
PHD finger protein 11
chr11_+_69176391 2.145 CCND1
cyclin D1
chr5_-_54317102 2.027 NM_001135604
NM_007036
ESM1

endothelial cell-specific molecule 1

chr5_+_71538456 2.004 MAP1B
microtubule-associated protein 1B
chr6_+_151688327 2.000 NM_144497
AKAP12
A kinase (PRKA) anchor protein 12
chr7_-_87687276 1.960 SRI
sorcin
chr6_-_112682573 1.918 LAMA4
laminin, alpha 4
chr8_-_93181091 1.913 NM_001198628
RUNX1T1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr3_+_137224266 1.907 NM_181897
PPP2R3A
protein phosphatase 2, regulatory subunit B'', alpha
chr6_-_112682459 1.892 NM_001105206
NM_001105207
NM_001105208
NM_001105209
NM_002290
LAMA4




laminin, alpha 4




chr6_-_152681171 1.847 NM_015293
SYNE1
spectrin repeat containing, nuclear envelope 1
chr1_-_149611768 1.843 NM_003944
SELENBP1
selenium binding protein 1
chr2_+_200879040 1.817 NM_001100422
NM_001100424
NM_001100423
SPATS2L


spermatogenesis associated, serine-rich 2-like


chr1_+_169421011 1.796 NM_001460
FMO2
flavin containing monooxygenase 2 (non-functional)
chr19_-_53305825 1.794 NM_001159322
NM_001159323
NM_003706
PLA2G4C


phospholipase A2, group IVC (cytosolic, calcium-independent)


chr12_-_14929991 1.776 NM_000900
NM_001190839
MGP

matrix Gla protein

chr12_-_9913199 1.770 CLEC2B
C-type lectin domain family 2, member B
chr3_+_62280435 1.753 NM_020685
C3orf14
chromosome 3 open reading frame 14
chr5_+_34723420 1.750 NM_001145523
RAI14
retinoic acid induced 14
chr4_+_38545741 1.734 NM_138389
FAM114A1
family with sequence similarity 114, member A1
chr10_+_71231649 1.715 NM_001130103
NM_080798
NM_080800
NM_080801
NM_080802
NM_080805
COL13A1





collagen, type XIII, alpha 1





chr10_+_71231693 1.682 COL13A1
collagen, type XIII, alpha 1
chr6_-_112682401 1.665 LAMA4
laminin, alpha 4
chr13_-_32757835 1.636 NM_178006
STARD13
StAR-related lipid transfer (START) domain containing 13
chr8_-_108579270 1.615 NM_001146
ANGPT1
angiopoietin 1
chr10_-_90702490 1.568 NM_001613
ACTA2
actin, alpha 2, smooth muscle, aorta
chr2_-_188127430 1.556 NM_001032281
NM_006287
TFPI

tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)

chr2_+_151922350 1.551 NM_007115
TNFAIP6
tumor necrosis factor, alpha-induced protein 6
chr3_+_11242666 1.545 NM_001098211
HRH1
histamine receptor H1
chr7_-_27186400 1.527 NM_153715
HOXA10
homeobox A10
chr2_-_133145539 1.517 NM_001077427
LYPD1
LY6/PLAUR domain containing 1
chr12_-_90100710 1.497 DCN
decorin
chr11_+_63060848 1.480 NM_004585
RARRES3
retinoic acid receptor responder (tazarotene induced) 3
chr1_-_171441234 1.454 TNFSF4
tumor necrosis factor (ligand) superfamily, member 4
chr8_+_75066117 1.452 NM_001195797
NM_015364
LY96

lymphocyte antigen 96

chr8_-_93176618 1.431 NM_001198629
NM_001198630
NM_001198632
NM_175635
RUNX1T1



runt-related transcription factor 1; translocated to, 1 (cyclin D-related)



chr1_+_157246305 1.383 NM_005531
IFI16
interferon, gamma-inducible protein 16
chr7_-_87687302 1.370 NM_003130
SRI
sorcin
chr21_+_29439768 1.341 C21orf7
chromosome 21 open reading frame 7
chr12_+_118100977 1.337 NM_014365
HSPB8
heat shock 22kDa protein 8
chr5_-_94250357 1.331 MCTP1
multiple C2 domains, transmembrane 1
chr17_-_44043361 1.299 NM_004502
HOXB7
homeobox B7
chr2_+_170044194 1.297 NM_152384
BBS5
Bardet-Biedl syndrome 5
chr8_-_13018123 1.286 NM_001164271
DLC1
deleted in liver cancer 1
chr1_-_161439487 1.282 NM_003617
RGS5
regulator of G-protein signaling 5
chr1_+_84402962 1.275 PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr5_-_111119846 1.264 NM_001142483
C5orf13
chromosome 5 open reading frame 13
chr10_+_124135574 1.258 NM_001195608
PLEKHA1
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1
chr1_-_56817717 1.251 PPAP2B
phosphatidic acid phosphatase type 2B
chr5_+_96237923 1.233 ERAP2
endoplasmic reticulum aminopeptidase 2
chr11_-_17147863 1.219 NM_002645
PIK3C2A
phosphoinositide-3-kinase, class 2, alpha polypeptide
chr3_-_115825742 1.213 NM_001164347
ZBTB20
zinc finger and BTB domain containing 20
chr8_-_23317620 1.211 NM_002318
LOXL2
lysyl oxidase-like 2
chr4_-_186693574 1.199 NM_001114107
NM_014476
PDLIM3

PDZ and LIM domain 3

chr1_-_101132993 1.196 NM_001033025
NM_001439
EXTL2

exostoses (multiple)-like 2

chrX_+_15428820 1.185 NM_203281
BMX
BMX non-receptor tyrosine kinase
chr8_-_23317577 1.185 LOXL2
lysyl oxidase-like 2
chr8_+_70567581 1.184 NM_001128205
NM_001128206
SULF1

sulfatase 1

chr8_-_13178399 1.180 DLC1
deleted in liver cancer 1
chr19_+_54723044 1.169 RCN3
reticulocalbin 3, EF-hand calcium binding domain
chr9_-_16717887 1.163 BNC2
basonuclin 2
chr8_-_93177057 1.150 NM_001198625
NM_001198626
NM_001198627
NM_001198631
NM_001198634
NM_001198679
RUNX1T1





runt-related transcription factor 1; translocated to, 1 (cyclin D-related)





chr1_+_43837096 1.147 PTPRF
protein tyrosine phosphatase, receptor type, F
chr4_-_70861301 1.141 NM_001891
CSN2
casein beta
chr12_+_10256682 1.115 NM_031412
GABARAPL1
GABA(A) receptor-associated protein like 1
chr16_+_8622974 1.111 NM_024109
METTL22
methyltransferase like 22
chr21_-_26175068 1.105 APP
amyloid beta (A4) precursor protein
chr2_+_201182187 1.105 AOX1
aldehyde oxidase 1
chr1_+_99884018 1.102 NM_017734
PALMD
palmdelphin
chr1_+_15637521 1.095 NM_007272
CTRC
chymotrypsin C (caldecrin)
chr12_-_9913724 1.084 NM_005127
CLEC2B
C-type lectin domain family 2, member B
chr5_+_15553288 1.082 NM_012304
FBXL7
F-box and leucine-rich repeat protein 7
chr1_+_19842309 1.076 NM_182744
NBL1
neuroblastoma, suppression of tumorigenicity 1
chr4_+_15313670 1.073 NM_004334
BST1
bone marrow stromal cell antigen 1
chr1_+_221966684 1.055 NM_001748
CAPN2
calpain 2, (m/II) large subunit
chr17_-_45617899 1.049 COL1A1
collagen, type I, alpha 1
chr2_+_102320148 1.042 NM_003856
IL1RL1
interleukin 1 receptor-like 1
chr1_-_103269356 1.035 COL11A1
collagen, type XI, alpha 1
chr10_-_126839056 1.009 NM_001329
CTBP2
C-terminal binding protein 2
chr3_+_185375362 0.993 AP2M1
adaptor-related protein complex 2, mu 1 subunit
chr10_+_53744043 0.990 NM_012242
DKK1
dickkopf homolog 1 (Xenopus laevis)
chr3_+_185375356 0.985 AP2M1
adaptor-related protein complex 2, mu 1 subunit
chr11_-_104332631 0.973 NM_033306
CASP4
caspase 4, apoptosis-related cysteine peptidase
chr2_-_188127294 0.972 TFPI
tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
chr20_+_42644633 0.971 PKIG
protein kinase (cAMP-dependent, catalytic) inhibitor gamma
chr10_-_126839000 0.968 CTBP2
C-terminal binding protein 2
chr6_+_153060722 0.965 NM_025107
MYCT1
myc target 1
chr4_-_16509446 0.960 NM_001130834
NM_001290
LDB2

LIM domain binding 2

chr3_+_185375370 0.954 AP2M1
adaptor-related protein complex 2, mu 1 subunit
chr4_-_16509354 0.948 LDB2
LIM domain binding 2
chr20_-_43972061 0.944 PLTP
phospholipid transfer protein
chr17_-_45619038 0.943 COL1A1
collagen, type I, alpha 1
chr3_+_45042754 0.938 NM_003278
CLEC3B
C-type lectin domain family 3, member B
chr9_+_132002692 0.938 NM_001128826
NCS1
neuronal calcium sensor 1
chr1_+_82038669 0.937 NM_012302
LPHN2
latrophilin 2
chr2_+_101874765 0.937 MAP4K4
mitogen-activated protein kinase kinase kinase kinase 4
chr9_-_116920232 0.929 NM_002160
TNC
tenascin C
chr7_-_22506320 0.928 NM_001164460
NM_207342
MGC87042

STEAP family protein MGC87042

chr2_-_151052391 0.922 NM_005168
RND3
Rho family GTPase 3
chr15_+_22619886 0.920 NM_022806
NM_022807
NM_022808
SNRPN


small nuclear ribonucleoprotein polypeptide N


chrX_-_10761729 0.920 NM_033290
MID1
midline 1 (Opitz/BBB syndrome)
chr2_-_179380301 0.917 NM_003319
NM_133378
NM_133379
NM_133432
NM_133437
TTN




titin




chr11_-_27679617 0.913 NM_170733
BDNF
brain-derived neurotrophic factor
chr20_+_9236446 0.913 NM_000933
PLCB4
phospholipase C, beta 4
chr8_-_17702665 0.912 NM_001001924
NM_001001925
MTUS1

microtubule associated tumor suppressor 1

chr3_+_185375379 0.906 AP2M1
adaptor-related protein complex 2, mu 1 subunit
chr7_+_89621624 0.903 NM_012449
STEAP1
six transmembrane epithelial antigen of the prostate 1
chr3_-_15357878 0.901 NM_001018009
SH3BP5
SH3-domain binding protein 5 (BTK-associated)
chr7_-_143213296 0.899 FAM115A
family with sequence similarity 115, member A
chr9_-_14076901 0.890 NFIB
nuclear factor I/B
chr1_+_169326641 0.890 NM_001002294
NM_006894
FMO3

flavin containing monooxygenase 3

chr8_+_144711619 0.881 NM_024736
GSDMD
gasdermin D
chr12_+_29193399 0.877 FAR2
fatty acyl CoA reductase 2
chr4_-_16509126 0.873 LDB2
LIM domain binding 2
chr22_-_34754343 0.870 NM_001082578
NM_001082579
RBFOX2

RNA binding protein, fox-1 homolog (C. elegans) 2

chr4_-_91979113 0.867 NM_183049
TMSL3
thymosin-like 3
chr19_-_4351470 0.867 NM_003025
SH3GL1
SH3-domain GRB2-like 1
chr22_-_41366550 0.866 NM_001165877
ATP5L2
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit G2
chr2_+_20510312 0.862 NM_004040
RHOB
ras homolog gene family, member B
chr4_+_91035025 0.861 NM_007351
MMRN1
multimerin 1
chr3_+_185375263 0.860 NM_001025205
NM_004068
AP2M1

adaptor-related protein complex 2, mu 1 subunit

chr10_+_63331018 0.857 NM_032199
ARID5B
AT rich interactive domain 5B (MRF1-like)
chr7_+_89621725 0.856 STEAP1
six transmembrane epithelial antigen of the prostate 1
chr12_+_76749199 0.847 NM_014903
NAV3
neuron navigator 3
chr1_+_162795328 0.841 NM_002585
PBX1
pre-B-cell leukemia homeobox 1
chr1_-_110735158 0.829 NM_004696
SLC16A4
solute carrier family 16, member 4 (monocarboxylic acid transporter 5)
chr1_-_20682541 0.825


chr9_+_123126652 0.825 GSN
gelsolin
chr19_-_41215610 0.817 NM_015526
CLIP3
CAP-GLY domain containing linker protein 3
chr4_+_26194643 0.813 NM_018317
TBC1D19
TBC1 domain family, member 19
chr3_-_170347019 0.812 NM_001105078
MECOM
MDS1 and EVI1 complex locus
chr7_+_6583560 0.810 NM_001134387
NM_001134388
NM_001134389
NM_018106
ZDHHC4



zinc finger, DHHC-type containing 4



chr4_+_146623405 0.808 NM_001003688
SMAD1
SMAD family member 1
chr17_-_44043278 0.807 HOXB7
homeobox B7
chr18_+_71051713 0.799 NM_005786
TSHZ1
teashirt zinc finger homeobox 1
chr4_-_5071996 0.799 NM_018659
CYTL1
cytokine-like 1
chr12_-_78831821 0.792 NM_001143886
PPP1R12A
protein phosphatase 1, regulatory (inhibitor) subunit 12A
chr2_-_188021117 0.786 NM_005795
CALCRL
calcitonin receptor-like
chr1_+_156229686 0.778 NM_018240
KIRREL
kin of IRRE like (Drosophila)
chr22_-_34566367 0.760 NM_001031695
NM_001082576
NM_001082577
NM_014309
RBFOX2



RNA binding protein, fox-1 homolog (C. elegans) 2



chr6_-_128883125 0.760 NM_002844
NM_001135648
PTPRK

protein tyrosine phosphatase, receptor type, K

chr1_+_78243181 0.758 NM_007034
DNAJB4
DnaJ (Hsp40) homolog, subfamily B, member 4
chr15_+_62467055 0.753 NM_016213
TRIP4
thyroid hormone receptor interactor 4
chr19_+_54722686 0.744 NM_020650
RCN3
reticulocalbin 3, EF-hand calcium binding domain
chr8_+_70567634 0.743 SULF1
sulfatase 1
chr7_+_75864755 0.741 NM_007155
ZP3
zona pellucida glycoprotein 3 (sperm receptor)
chr11_+_65414677 0.739 CCDC85B
coiled-coil domain containing 85B
chr18_+_20260603 0.735 NM_018439
IMPACT
Impact homolog (mouse)
chr19_-_56946911 0.735 NM_001193306
NM_002029
FPR1

formyl peptide receptor 1

chr21_-_45118037 0.729 NM_004339
PTTG1IP
pituitary tumor-transforming 1 interacting protein
chr18_+_31488530 0.727 NM_020474
GALNT1
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 1 (GalNAc-T1)
chr13_+_48967746 0.712 NM_001040443
PHF11
PHD finger protein 11
chr1_-_168310232 0.711 NM_014970
KIFAP3
kinesin-associated protein 3
chr11_-_8695974 0.711 ST5
suppression of tumorigenicity 5
chr18_+_20260609 0.708 IMPACT
Impact homolog (mouse)
chr3_-_170346760 0.705 NM_001105077
NM_001163999
NM_005241
MECOM


MDS1 and EVI1 complex locus


chr7_-_94902149 0.700 NM_000305
NM_001018161
PON2

paraoxonase 2

chr3_+_185375341 0.699 AP2M1
adaptor-related protein complex 2, mu 1 subunit
chr1_+_163084934 0.694 PBX1
pre-B-cell leukemia homeobox 1
chr7_+_115926679 0.692 NM_001233
NM_198212
CAV2

caveolin 2

chr10_-_29794484 0.689 SVIL
supervillin
chr1_-_56817568 0.684 PPAP2B
phosphatidic acid phosphatase type 2B
chr2_+_183290912 0.684 DNAJC10
DnaJ (Hsp40) homolog, subfamily C, member 10
chr3_-_69120188 0.676 C3orf64
chromosome 3 open reading frame 64
chr4_+_41056378 0.675 LIMCH1
LIM and calponin homology domains 1
chr4_+_124537334 0.673 NM_199327
SPRY1
sprouty homolog 1, antagonist of FGF signaling (Drosophila)
chr1_+_143807748 0.668 NM_004892
SEC22B
SEC22 vesicle trafficking protein homolog B (S. cerevisiae) (gene/pseudogene)
chr10_-_104252394 0.665 NM_005736
ACTR1A
ARP1 actin-related protein 1 homolog A, centractin alpha (yeast)

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.66 4.52e-03 GO:2000026 regulation of multicellular organismal development
1.36 4.90e-03 GO:0048523 negative regulation of cellular process
1.33 1.12e-02 GO:0048519 negative regulation of biological process
1.56 1.68e-02 GO:0050793 regulation of developmental process
1.97 3.60e-02 GO:0022603 regulation of anatomical structure morphogenesis

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.28 1.15e-04 GO:0005886 plasma membrane
1.27 1.21e-04 GO:0071944 cell periphery
1.40 8.74e-04 GO:0005576 extracellular region
1.53 1.50e-03 GO:0044421 extracellular region part
2.04 2.19e-03 GO:0005578 proteinaceous extracellular matrix
1.50 3.16e-02 GO:0042995 cell projection
3.07 4.51e-02 GO:0030427 site of polarized growth
1.49 4.82e-02 GO:0005615 extracellular space

Nothing significant found in function category.